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Therefore, histamine has differential consequences on neuropathic pain dependent upon the histamine receptor subtype it can be bound to. As described Formerly, this assessment aims to summarize histamine‐mediated effects on neuropathic pain. Consequently, the next sections of this critique focus on mechanisms fundamental histamine‐mediated anal
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The activation of CB1 and CB2 inhibits the development of intracellular cAMP, as a result leading to an incredible reduction of the excitatory impact within the neurons [88,89]. In addition, the activation of CB2 can even more prevent the mast cell degranulation and the discharge of pro-inflammatory mediators, earning the reduction in pain sensatio